Wingman Safety Brief

Sildenafil and tadalafil safety information

ED treatment can be appropriate for many adults, but it is not safe for everyone. Your clinician needs honest information about heart health, blood pressure, medications and other risk factors.

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The direct answer

Never combine common prescription ED medications with nitrates or recreational poppers. Seek emergency help for chest pain, severe symptoms or an erection lasting more than four hours.

Medicines that require special attention

Nitrates, poppers, some blood-pressure medicines and several other therapies can create serious interactions or require a different plan. Do not stop a prescribed medicine on your own.

✓List every prescription and non-prescription medicine
✓Include supplements and recreational substances
✓Tell the clinician about recent medication changes

Health history matters

Recent heart or stroke events, unstable symptoms, very low blood pressure, certain eye conditions, kidney disease or liver disease can change what is safe.

Know when to get urgent help

Call 911 for chest pain, fainting, severe breathing difficulty or stroke symptoms. An erection lasting more than four hours requires emergency care. Sudden vision or hearing loss also needs urgent assessment.

Help for erection difficulties

ED symptoms and treatment options

Sildenafil and tadalafil help blood vessels relax, improving blood flow during sexual stimulation. That can make it easier to get and keep an erection firm enough for sex.

Trouble getting an erection?

Wanting sex but struggling to get firm enough can be a sign of ED. Find out how prescription treatment may help.

Difficulty getting an erection

Losing your erection during sex?

ED can also mean getting an erection but not keeping it. Learn about losing firmness and when medication may be an option.

Difficulty keeping an erection

Worrying about losing your erection?

Pressure to perform can make erection difficulties worse. Medication may help the erection response, but anxiety may also need separate support.

Performance anxiety and ED

Sexual stimulation is still needed. These medicines do not increase desire and are not suitable for everyone; a prescription is required.

When to seek medical advice

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Useful next steps

Nitrates & Poppers Read more Drug Interactions Read more Side Effects Read more